PUBLICATIONS: PEER-REVIEWED PUBLICATIONS
(*Indicates Dr. Lugo as the corresponding author. # indicates Baylor graduate student. † indicates Baylor undergraduate student)
Womble, P. D. #, Hodges, S. L. #, Nolan, S. O. #, Binder, M. S. #, Holley, A. J. #, Herrera, R. †, Senger, S. †, Kwok, E. †, Narvaiz, D. A. #, Faust, A†., Hernandez-Zegada, C. J. †, Kwon, R. Y., Lugo, J. N. * (2021). A vitamin D enriched diet attenuates sex-specific behavioral deficits, increases the lifespan, but does not rescue bone abnormalities in a mouse model of cortical dysplasia. Epilepsy and Behavior. Sep 9; 124:108297. doi: 10.1016/j.yebeh.2021.108297.
Binder, M. S. #, Pranske, Z. J. †, Lugo, J. N. * (2021). Evaluating the DeepSqueak and Mouse Song Analyzer vocalization analysis systems in C57BL/6J, FVB.129, and FVB neonates. Journal of Neuroscience Methods. Dec 1; 364: 109356. DOI: 10.1016/j.jneumeth.2021.109356
O’Brien, M., Rundell, Z. C., Nemec, M.D., Langan, L. M., Back, J. A., Lugo, J. N. * (2021). A comparison of four commercially available RNA extraction kits for wastewater surveillance of SARS-CoV-2 in a college population. Science of the Total Environment. Dec 20; 801:149595. doi: 10.1016/j.scitotenv.2021.149595.
Hodges, S. L. #, Womble, P. D. #, Kwok, E. M. †, Darner, A. M. †, Senger, S. S. †, Binder, M. S. #, Faust, A. M. †, Condon, S. M. †, Nolan, S. O. #, Quintero, S. I. †, Lugo, J. N. * (2021). Rapamycin, but not minocycline, significantly alters ultrasonic vocalization behavior in C57BL/6J pups in a flurothyl seizure model. Behavioural Brain Research. July 23; 410: 113317. doi: 10.1016/j.bbr.2021.113317.
Nolan, S. O. #, Hodges, S. L., Okoh, J. T. †, Binder, M. S. #, Lugo, J. N. (2021). Prenatal high-fat diet rescues communication deficits in Fmr1 mutant mice in a sex-specific manner. Developmental Neuroscience. Developmental Neuroscience. Jan 4:1-11.
Reynolds, C. D. †, Suzanne, S. O. #, Smith, G. D. #, Jefferson, T. S. †, Hodges, S. L. #, Brewster, A. L., Lugo, J. N. (2020). Increased expression of Fragile X mental retardation protein in malformative lesions of patients with focal cortical dysplasia. Neuroreport. Oct 7;31(14):1036-1041. doi:10.1097/WNR.0000000000001517.
Binder, M. S. #, Kim, A. D. †, Lugo, J. N. (2020). An acute seizure prior to memory reactivation transiently impairs associative memory performance in C57BL/6J mice. Aug 18; 27(9):340-345. doi: 10.1101/lm.050633.119.
Binder, M. S. #, Nolan, S. O. #, Lugo, J. N. (2020). A comparison of the Avisoft (v.5.2) and MATLAB Mouse Song Analyzer (v.1.3) vocalization analysis systems in C57BL/6, Fmr1-FVB.129, NS-Pten-FVB, and 129 mice. Journal of Neuroscience Methods, Aug 14: 108913. doi: 10.1016/j.jneumeth.2020.108913.
Huebschman, J. L. †, Hodges, S. L. #, Reynolds, C. D. †, Nolan, S. O. #, Lugo, J. N. (2020). A single episode of early-life status epilepticus impacts neonatal ultrasonic vocalization behavior in the Fmr1 knockout mouse. Epilepsy and Behavior, 111:107279. doi: 10.1016/j.yebeh.2020.107279.
Hodges, S. L. # and Lugo, J. N. (2020). Therapeutic role of targeting mTOR signaling and neuroinflammation in epilepsy. Epilepsy Research. Jan 30;161:106282.
Hodges, S. L. #, Nolan, S. O. #, Tomac, L. A. †, Muhammad, I. D. A. †, Binder, M. S. #, Taube, J. H., Lugo, J. N. (2020). Lipopolysaccharide-induced inflammation leads to acute elevations in pro-inflammatory cytokine expression in a mouse model of Fragile X syndrome. Physiology and Behavior Mar 1;215:112776
Nolan, S. O. #, Hodges, S. L. #, Lugo, J. N. (2020). High-throughput analysis of vocalizations reveals sex-specific changes in Fmr1 mutant pups. Genes Brain and Behavior. Feb;19(2):e12611.
Binder, M. S. #, Jones, D. G. †, Hodges, S. L. #, Lugo, J. N. (2020). NS-Pten adult knockout mice display both quantitative and qualitative changes in urine-induced ultrasonic vocalizations. Behavioral Brain Research. Jan 27;378:112189.
Hodges, S. L. #, Reynolds, C. D. †, Nolan, S. O. #, Huebschman, J. L. †, Okoh, J. T. †, Binder, M. S. #, Lugo, J. N. (2019). A single early-life seizure results in long-term behavioral changes in the adult Fmr1 knockout mouse. Epilepsy Research. Nov;157:106193.
Binder, M. S. #, Nolan, S. O. #,, Lugo, J. N. (2019). Neuronal subset-specific Pten-deficient mice do not exhibit deficits in sensorimotor gating processes. F1000Research 2019, 8:1727.
Nolan, S.O., Hodges, S.L., Condon, S.M., Muhammed, I.D.A., Tomac, L.A., Binder, M.S., Reynolds, C.D., Lugo, J.N. (2019). High seizure load during sensitive periods of development leads to broad shifts in ultrasonic vocalization behavior in neonatal male and female C57BL/6J mice. Epilepsy Behav. 2019 Apr 22;95:26-33. doi: 10.1016/j.yebeh.2019.03.037. [Epub ahead of print]
Nolan, S.O., Jefferson, T.S., Reynolds, C.D., Smith, G.D., Holley, A.J., Hodges, S.L., Lugo, J. N. (2019). Neuronal deletion of phosphatase and tensin homolog results in cerebellar motor learning dysfunction and alterations in intracellular signaling. Neuroreport. 2019 May 22;30(8):556-561. doi: 10.1097/WNR.000000000000124
Hodges, S. L. #, Reynolds, C. D. †, Smith, G. D. #, Jefferson, T. S. †, Gao, N. †, Morrison, J. B. †, White, J. †, Nolan, S. O. #, Lugo, J. N. * (2018). Neuronal subset-specific deletion of Pten results in aberrant Wnt signaling and memory impairments. Brain Res. 1699:100-106. doi: 10.1016/j.brainres.2018.08.007.
Binder, M. S. #, Hernandez-Zegada, C. J. †, Potter, C. T. †, Nolan, S. O#., Lugo, J. N.* (2018). A comparison of the Avisoft (5.2) and Ultravox (2.0) recording systems: Implications for early-life communication and vocalization research. J Neurosci Methods. 309:6-12. doi:0.1016/j.jneumeth.2018.08.015.
Hodges, S. L. # & Lugo, J. N. * (2018). Wnt/β-catenin signaling as a potential target for novel epilepsy therapies. Epilepsy Research.146:9-16. doi: 10.1016/j.eplepsyres.2018.07.002. Epub 2018 Jul 24. Review.
Hodges, S. L. #, Reynolds, C. D. †, Smith, G. D. #, Jefferson, T. S. †, Nolan, S. O. #, Lugo, J. N. * (2018). Molecular interplay between hyperactive mammalian target of rapamycin signaling and Alzheimer’s disease neuropathology in the NS-Pten knockout mouse model. Neuroreport. 2018 Jun 29. doi: 10.1097/WNR.0000000000001081. [Epub ahead of print]
Nolan, S.O. # & Lugo, J. N.* (2018). Reversal learning paradigm reveals deficits in cognitive flexibility in the Fmr1 knockout male mouse. F1000Res. 2018 Jun 7;7:711. doi: 10.12688/f1000research.14969.1. eCollection 2018.
Frigerio, F., Flynn, C., Han, Y., Lyman, K., Lugo, J. N., Ravizza, T., Ghestem, A., Pitsch, J., Becker, A., Anderson, A. E., Vezzani, A., Chetkovich, D., Bernard, C. (2018). Neuroinflammation alters integrative properties of rat hippocampal pyramidal cells. Molecular Neurobiology. Feb 9. doi: 10.1007/s12035-018-0915-1.
Hodges, S.L. #, Nolan, S.O. #, Taube, J.H., Lugo, J.N. * (2017). Adult Fmr1 knockout mice present with deficiencies in hippocampal interleukin-6 and tumor necrosis factor-α expression. NeuroReport. Dec 13;28(18):1246-1249. 28915148.
Binder, M. S. # & Lugo, J. N. * (2017). NS-Pten knockout mice show sex- and age-specific differences in ultrasonic vocalizations. Brain and Behavior. Oct 18;7(11):e00857. 29201556.
Nolan, S.O. #, Reynolds, C. D. †, Smith, G. D. #, Holley, A. J. #, Escobar, E. †, Chandler, M. A. †, Volquardsen, M. †, Jefferson, T. †, Pandian, A. †, Smith, T. †, Nolan, S.O. #, Huebschman, J.L. †, and Lugo, J. N. * (2017). Deletion of Fmr1 results in sex-specific changes in behavior. Brain and Behavior. Aug 25;7(10):e00800. 29075560.
Chernoff, N., Hill D,J., Diggs, D.L., Faison, B.D., Francis, B.M., Lang, J.R., Larue, M.M., Le, T.T., Loftin, K.A., Lugo, J.N., Schmid, J.E., Winnik, W.M. (2017). A critical review of the postulated role of the non-essential amino acid, β-N-methylamino-L-alanine, in neurodegenerative disease in humans. J Toxicol Environ Health B Crit Rev. 2017;20(4):1-47. doi: 10.1080/10937404.2017.1297592.
Reynolds, C. D. †, Nolan, S.O. #, Huebschman, J.L. †, Hodges, S.L. #, Lugo, J.N. * (2017). Early-life status epilepticus acutely impacts select quantitative and qualitative features of neonatal vocalization behavior: Spectrographic and temporal characterizations in C57BL/6 mice. Epilepsy Behav. 2017 May 30;72:58-62. doi: 10.1016/j.yebeh.2017.04.025.
Hodges, S. L. #, Nolan, S. O. #, Reynolds, C. D. †, Lugo, J. N. * (2017). Spectral and temporal properties of calls reveal deficits in ultrasonic vocalizations of adult Fmr1 knockout mice. Behavioral Brain Research. May 26;332:50-58. doi: 10.1016/j.bbr.2017.05.052.
Lugo, J.N. *, Thompson, M. H, †, Huber, P., Smith, G. #, Kwon, R.Y. (2017). Neuron subset-specific Pten deletion induces abnormal skeletal activity in mice. Experimental Neurology. May;291:98-105. doi: 10.1016/j.expneurol.2017.02.002.
Smith, G. D. #, Ahmed, N. †, Arbuckle, E. #, Lugo, J.N. * (2017). Early-life status epilepticus induces long-term deficits in anxiety and spatial learning in mice. International Journal of Epilepsy. http://dx.doi.org/10.1016/j.ijep.2016.12.005.
Reynolds, C.D.†, Nolan. S.O.#, Jefferson. T.†, J.N.* (2016). Sex-specific and genotype-specific differences in vocalization development in FMR1 knockout mice. Neuroreport. Dec 14;27(18):1331-1335.
Smith, G.D. #, White, J. †, & Lugo, J. N.* (2016). Superimposing Status Epilepticus on Neuron Subset-Specific PTEN Haploinsufficient and Wild Type Mice Results in Long-term Changes in Behavior. Scientific Reports.Nov 7;6:36559. doi: 10.1038/srep36559.
Reynolds, C. #, Smith, G. D. †, Jefferson, T. S. #, Lugo, J. N. * (2016). Early-life seizures produce a sex-specific suppression of ultrasonic vocalizations in neonatal mice. Epilepsia. Sep;57(9):1377-85. doi: 10.1111/epi.13450.
Smith, G. D. #, Gao, N. †, Lugo, J. N. * (2016). Kv4.2 knockout mice display learning and memory deficits in the Lashley maze. F1000 Research. 5:2456. doi: 10.12688/f1000research.9664.2. eCollection 2016.
Holley, A. J. # & Lugo, J. N*. (2016). Effects of an Acute Seizure on Associative Learning and Memory. Epilepsy and Behavior, Jan;54:51-7.
Reynolds, C. †, Smith, G. D. #, Jefferson, T. S. †, Lugo, J. N. * (2015). Comparison of Equivalence Between Two Commercially Available S499-phosphorylated FMRP Antibodies in Mice. PLOS One. Nov 18;10(11):e0143134. doi: 10.1371/journal.pone.0143134.
Arbuckle, E. P., Smith, G., Gomez, M., Lugo, J. N. (2015). Testing for Odor Discrimination and Habituation in Mice. Journal of Visualized Experiments. May 5(99) e52615.
Elston, T. W., Pandian, A., Smith, G. D., Holley, A. J., Gao, N., Lugo J. N. (2014). Aniracetam Does Not Alter Cognitive and Affective Behavior in Adult C57BL/6J Mice. PLoS One. Aug 6;9(8):e104443. doi: 10.1371/journal.pone.0104443. eCollection 2014.
Lugo, J. N., Smith, G. D., Arbuckle, E. P., White, J., Holley A, J., Floruta, C. M., Ahmed, N., Gomez, M. C., Okonkwo, O. (2014). Deletion of PTEN produces autism-like behavioral deficits and alterations in synaptic proteins. Front Mol Neurosci. Apr 16;7:27. doi: 10.3389/fnmol.2014.00027. eCollection 2014.
Lugo, J. N., Smith, G., Holley, A. (2014). Trace fear conditioning in mice. Journal of Visualized Experiments. Mar 20;(85). doi: 10.3791/51180.
Lugo, J.N., Swann, J.W, Anderson A.E.(2014). Early-life seizures result in deficits in social behavior and learning. Exp Neurol. Jun;256:74-80. doi: 10.1016/j.expneurol.2014.03.014.
Lugo, J. N., Smith, G. D., Morrison, J. B., White, J. (2013). Deletion of PTEN produces deficits in conditioned fear and increases fragile X mental retardation protein. Learning and Memory. Nov 15;20(12):670-3. doi: 10.1101/lm.032839.113.
Brewster, A. L., Lugo, J. N., Patil, V. V., Lee, W. L., Qian, Y., Vanegas, F., Anderson, A. E. (2013). Rapamycin reverses status epilepticus-induced memory deficits and dendritic damage. PLOS ONE. 8(3):e57808. PMID: 23536771
Marcelin, B., Lugo, J.N., Brewster, A. L., Liu, Z., Lewis, A. S., McClelland, S., Chetkovich, D. M., Baram, T. Z., Anderson, A. E., Becker, A., Esclapez, M., Bernard C. (2012). Differential dorso-ventral distributions of Kv4.2 and hyperpolarization-activated cyclic adenosine monophosphate gated channel (HCN) proteins confer distinct integrative properties to hippocampal CA1 pyramidal cell distal dendrites. Journal of Biological Chemistry. May 18;287(21):17656-61. PMID:22511771
Lugo, J. N., Brewster, A. L., Spencer, C.M., Anderson, A. E. (2012). Kv4.2 knockout mice show hippocampal-dependent learning and memory deficits. Learning and Memory, Apr 13;19(5):182-9
Sunnen, C.N., Brewster, A. L., Lugo, J. N., Venegas, F., Turcios, E., Mukhi, S., Parghi, D., D’Arcangelo, D., Anderson, A. E. (2011). Inhibition of the mammalian target of rapamycin blocks epilepsy progression in NS-PTEN conditioninal knockout mice. Epilepsia, Nov;52(11): 2065-75. PMID: 22505720
Ljungberg, C., Sunnen, C.N., Lugo, J. N., Anderson, A. E. & D’Arcangelo, G. D. (2009). Rapamycin suppresses seizures and neuronal hypertrophy in a mouse model of cortical dysplasia. Disease Models & Mechanisms. Jul-Aug;2(7-8): 389-398. PMCID: PMC2707106.
Barnwell, L. F. S., Lugo, J. N., Lee, W., Willis, S. E., Gertz, S. J., Hrachovy, R. A., Anderson, A. E., (2009). Kv4.2 knockout mice demonstrate increased susceptibility to convulsant stimulation. Epilepsia. Jul; 50(7): 1741-1751. PMCID: PMC2925051.
Lugo, J. N., Barnwell, L. F., Johnston, L. D., Kim, R., Feng, C., Hrachovy, R. A., Sweatt, J. D., & Anderson, A. E. (2008). Altered phosphorylation and localization of the A-type channel, Kv4.2 in status epilepticus. Journal of Neurochemistry. Aug;106(4): 1929-40. PMCID2678944.
Jung, S., Jones, T. D., Lugo, J. N., Sherrin, A. H., Sherrin, J. W., D’Ambrosio, R., Anderson, A. E., Poolos, N. P. (2007). Progressive Dendritic HCN Channelopathy during Epileptogenesis in the Rat Pilocarpine Model of Epilepsy. Journal of Neuroscience. 27(47), 13012-12021. PMID: 18513371.
Gass, G. T., Jenkins, W. J., Marino, M. D., Lugo Jr., J. N., Kelly, S.J. (2007). Alcohol exposure during development: Analysis of effects on female sexual behavior. Alcoholism: Clinical and Experimental Research. 31(12), 2065-2072. PMID: 17949467.
Lugo Jr., J. N., Wilson, M. A., Kelly, S. J. (2006). Perinatal ethanol exposure alters met-enkephalin levels of male and female rats. Neurotoxicology & Teratology, 28(2), 238-244. PMID: 16457985.
Lugo Jr., J. N., Marino, M. D. Gass, J. T., Wilson, M. A., & Kelly, S. J. (2006). Alcohol exposure during development reduces resident aggression and testosterone in rats. Physiology & Behavior, 87(2), 330-337. PMID: 12724179.
Lugo Jr., J. N., Marino, M D., Cronise, K., Kelly, S. J. (2003). Effects of alcohol exposure during development on social behavior in rats. Physiology and Behavior, 78(2), 185-194. PMID: 12576115.
Marino, M., Cronise, K., Lugo, J. N., & Kelly, S. J. (2002). Ultrasonic Vocalizations and Maternal-Infant Interactions in a Rat Model of Fetal Alcohol Syndrome. Developmental Psychobiology, 41(4), 341-351. PMID: 12430158.
PUBLICATIONS: OTHER
Lugo, J. N., Lee, W., & Anderson, A. E. (2009). Epilepsy genes- A. Single gene mutations as a cause of epilepsy: Post-translational modification of ion channels in epilepsy. In P. A. Schwartzkroin (Ed.), Encyclopedia of Basic Epilepsy Research. Oxford, UK: Elsevier Ltd., 658-662.
Wilson, M. A., Burghardt, P. R., Lugo Jr., J. N., Primeaux, S. D., Wilson, S. P. (2003). Effect of amygdalar opioids on the anxiolytic properties of ethanol. Annals of the New York Academy of Sciences (986): The Amygdala in Brain Function: Basic and Clinical Approach., 472-475. PMID: 12724179.